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Science of Balance Support

The Science ofBalance Support

What it is

Lipo Flavonoid Advanced Balance Support is a once daily supplement formulated to help mitigate the risks of dizziness, balance issues, falls, and related declines in quality of life.

Spells of dizziness, swaying and balance dysfunction are common, especially as you get older, and can increase falls, depression, social isolation, fear, and overall dysfunction - all contributing to poor health and outcomes. Nutrition plays a key role in the health of your inner ear and the balance signals it sends to your brain so we developed a cost effective, over-the-counter daily supplement with ingredients clinically shown to be important for inner ear balance.

Ingredients

High absorption formula for optimal nutrient delivery of the most essential ear health ingredients

  • Vitamin D3 (as cholecalciferol)
  • Vitamin B1 (as thiamine mononitrate)
  • Vitamin B2 (as riboflavin)
  • Vitamin B3 (as niacinamide)
  • Vitamin B6 (as pyridoxine HCI)
  • Folate (as L-5 methyl tetrahydrofolate calcium)
  • Vitamin B12 (as cyanocobalamin)
  • Pantothenic Acid (as d-calcium pantothenate)
  • Ginkgo Biloba (leaf)
  • Lemon Bioflavonoid Complex

How it Works

B Complex (Vitamins B1, B6, & B12)

A Vitamin B Complex made up of B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin), which are essential for maintaining a healthy nervous system. These neurotropic B vitamins act as coenzymes and protect nerves from damage, helping ensure the balance signals the vestibular system transmits reach the brain. Deficiencies in these vitamins can lead to neurological diseases or malfunctions, but even without a proven deficiency, supplementing them can even improve certain neurological conditions.

Bioflavonoids

Bioflavonoids have over 60 years of clinical use in relieving vertigo and tinnitus symptoms. The eriodictyol glycoside found in bioflavonoids can improve microcirculation and prevent fatty deposits in the inner ear, while also potentially blocking histamine production. Additionally, hesperetin, a derivative of eriodictyol, can prevent neurodegenerative diseases by reversing the factors that cause them, such as oxidative stress and neuroinflammation. Its ability to inhibit apoptotic cell death makes hesperetin a promising drug for preventing and treating neurodegenerative conditions.

Ginkgo Biloba

Ginkgo Biloba is believed to improve blood flow throughout the inner ear by dilating blood vessels and reducing blood viscosity, which can enhance circulation to the small capillaries and hair cells in the ear. It also has antioxidant properties that can protect against oxidative stress and reduce inflammation in the inner ear. Additionally, Ginkgo Biloba may improve neurotransmitter function in the brain and enhance cognitive function, which can help with processing balance signals sent from the vestibular system to the brain.

Vitamin D

The hormonally active form of Vitamin D, known as dihydroxyvitamin D3 (1,25(OH)2D3), is responsible for stimulating active intestinal calcium absorption through its genomic actions, helping key nutrients absorb into the body faster without being wasted.

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*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

*Survey data on file

REFERENCES:

What is it?

  1. Balatsouras DG, Koukoutsis G, Fassolis A, Moukos A, Apris A. Benign paroxysmal positional vertigo in the elderly: current insights. Clin Interv Aging. 2018;13:2251-2266
  2. Hobeika CP. Equilibrium and Balance in the Elderly. Ear, Nose & Throat Journal. 1999;78(8):558-566. doi:10.1177/014556139907800810
  3. Shoair OA, Nyandege AN, Slattum PW. Medication-related dizziness in the older adult. Otolaryngol Clin North Am. 2011 Apr;44(2):455-71, x. doi: 10.1016/j.otc.2011.01.014. PMID: 21474017.
  4. Sfakianaki I, Binos P, Karkos P, Dimas GG, Psillas G. Risk Factors for Recurrence of Benign Paroxysmal Positional Vertigo. A Clinical Review. J Clin Med. 2021 Sep 24;10(19):4372. doi: 10.3390/jcm10194372. PMID: 34640391; PMCID: PMC8509726.
  5. Jeong SH, Lee SU, Kim JS. Prevention of recurrent benign paroxysmal positional vertigo with vitamin D supplementation: a meta-analysis. J Neurol. 2022 Feb;269(2):619-626. doi: 10.1007/s00415-020-09952-8. Epub 2020 Aug 7. PMID: 32767116.
  6. Ginde AA, Liu MC, Camargo CA. Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988-2004. Arch Intern Med. 2009;169(6):626–632. doi:10.1001/archinternmed.2008.604
  7. Sokolova L, Hoerr R, Mishchenko T. Treatment of Vertigo: A Randomized, Double-Blind Trial Comparing Efficacy and Safety of Ginkgo biloba Extract EGb 761 and Betahistine. Int J Otolaryngol. 2014;2014:682439. doi: 10.1155/2014/682439. Epub 2014 Jun 25. PMID: 25057270; PMCID: PMC4099171.
  8. Wolfgang Issing, Peter Klein, and Michael Weiser. The Homeopathic Preparation Vertigoheel® Versus Ginkgo biloba in the Treatment of Vertigo in an Elderly Population: A Double-Blinded, Randomized, Controlled Clinical Trial. The Journal of Alternative and Complementary Medicine.Feb 2005.155-160.
  9. Spiegel R, Kalla R, Mantokoudis G, Maire R, Mueller H, Hoerr R, Ihl R. Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials. Clin Interv Aging. 2018 Jun 13;13:1121-1127. doi: 10.2147/CIA.S157877. PMID: 29942120; PMCID: PMC6005330.

Balance Support Ingredients and Mechanisms of Action

  1. “Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) contribute essentially to the maintenance of a healthy nervous system. Their importance is highlighted by many neurological diseases related to deficiencies in one or more of these vitamins, but they can improve certain neurological conditions even without a (proven) deficiency”. Calderón-Ospina, C: B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin, CNS Neurosci Ther 2020 Jan;26(1):5-13
  2. “The ability of hesperetin to reverse the different inducers of neurodegenerative diseases, including elevated oxidative stress, neuroinflammation, and apoptotic cell death, making hesperetin a candidate drug for the prevention of neurodegenerative conditions”. Khan, A: Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders, Antioxidants (Basel). 2020 Jul; 9(7): 609
  3. “Ginkgo Biloba improves inner ear and cerebral blood flow by decreasing blood viscosity; it also improves mitochondrial function and energy metabolism, which altogether may play a role in improving inner ear and brain function in elderly people with dementia who often have vascular disorders and compromised mitochondrial function” Spiegel R, et al: Ginkgo biloba extract alleviates neurosensory symptoms in patients (with dementia): a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials. Clin Interv Aging2018 Jun 13; 13:1121-1127
  4. “1,25Dihydroxyvitamin D3 (1,25(OH)2D3) the hormonally active form of vitamin D, through its genomic actions, is the major stimulator of active intestinal calcium absorption which involves calcium influx, translocation of calcium through the interior of the enterocyte and basolateral extrusion of calcium by the intestinal plasma membrane pump”. Christakos, S et al: Vitamin D and Intestinal Calcium Absorption Mol Cell Endocrinol. 2011 December 5; 347(1-2): 25–29

Folate & B vitamins

  1. Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, Edmonds JT. Age-related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin Nutr. 1999 Mar;69(3):564-71. doi: 10.1093/ajcn/69.3.564. PMID: 10075346.
  2. Curhan SG, Stankovic KM, Eavey RD, Wang M, Stampfer MJ, Curhan GC. Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. Am J Clin Nutr. 2015 Nov;102(5):1167-75. doi: 10.3945/ajcn.115.109314. Epub 2015 Sep 9. PMID: 26354537; PMCID: PMC4625586.
  3. Collaboration HLT. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ. 1998 Mar 21;316(7135):894-8. PMID: 9569395; PMCID: PMC28491.
  4. Lasisi AO, Fehintola FA, Yusuf OB. Age-related hearing loss, vitamin B12, and folate in the elderly. Otolaryngol Head Neck Surg. 2010 Dec;143(6):826-30. doi: 10.1016/j.otohns.2010.08.031. Epub 2010 Oct 25. PMID: 21109085.
  5. Gocer C, et al (2009) Homocysteine, Folate and Vitamin B12 Concentrations in Middle Aged Adults Presenting with Sensorineural Hearing Impairment Int. Adv. Otol. 2009; 5:(3) 340-344
  6. Karli R, Gül A, Uğur B. Effect of vitamin B12 deficiency on otoacoustic emissions. Acta Otorhinolaryngol Ital. 2013 Aug;33(4):243-7. PMID: 24043911; PMCID: PMC3773962
  7. Petridou AI, Zagora ET, Petridis P, Korres GS, Gazouli M, Xenelis I, Kyrodimos E, Kontothanasi G, Kaliora AC. The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial. Nutrients. 2019 Dec 12;11(12):3037. doi: 10.3390/nu11123037. PMID: 31842394; PMCID: PMC6950042.

Ginkgo

  1. Nguyen T, Alzahrani T. Ginkgo Biloba. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK541024/#

Vitamin D

  1. Sfakianaki I, Binos P, Karkos P, Dimas GG, Psillas G. Risk Factors for Recurrence of Benign Paroxysmal Positional Vertigo. A Clinical Review. J Clin Med. 2021 Sep 24;10(19):4372. doi: 10.3390/jcm10194372. PMID: 34640391; PMCID: PMC8509726.

Bioflavonoids

  1. Creston JE, Gillespie MR, Larson AL. Bioflavonoid Therapy in Sensorineural Hearing Loss: A Double-Blind Study. Arch Otolaryngol. 1965;82(2):159–165. doi:10.1001/archotol.1965.00760010161015

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