Science of Hearing Support

The Science ofHearing Support

The Science Behind Lipo Flavonoid Advanced Hearing Support Formula

Learn more about the science that went into this unique supplement.

What it is

A once daily supplement with an innovative formula full of ingredients clinically proven to help reduce the risk of future hearing decline and preserve healthy hearing.

When you can’t hear, you can’t connect. Losing your hearing distances you from those around you and can lead to depression, social isolation, fear, and overall dysfunction - all contributing to poor health and outcomes.

Many things can cause hearing loss, so for a supplement to be impactful on hearing loss it needs to support several different areas of the ear that could need help.

It’s estimated that as many as 40% of older adults are deficient in vitamin B12, a nutrient important for neurological support of the inner ear.

Published literature shows a significant association between B12 deficiency and cochlear dysfunction. Supplementation can help.


High absorption formula for optimal nutrient delivery of the most essential ear health ingredients

  • Vitamin C (as ascorbic acid)
  • Vitamin B1 (as thiamine mononitrate)
  • Vitamin B2 (as riboflavin)
  • Vitamin B3 (as niacinamide)
  • Vitamin B6 (as pyridoxine HCI)
  • Folate (as L-5 methyl tetrahydrofolate calcium)
  • Vitamin B12 (as cyanocobalamin)
  • Pantothenic Acid (as d-calcium pantothenate)
  • Magnesium (as magnesium oxide)
  • Ginkgo Biloba (leaf)
  • Lemon Bioflavonoid Complex

How it Works

L Methyl Folate

L Methyl Folate is important for our ears because it helps prevent premature hearing loss by improving cochlear homocysteine metabolism and reducing oxidative stress by increasing nutrient delivery and absorption in the cochlea. A lack of Folate in the body is often caused by the liver being unable to properly process it from the food we eat. But this ingredient does not need to be converted in your liver, bypassing it and going directly to the bloodstream instead; ensuring you’re not missing essential nutrients.

B Complex (Vitamins B1, B6 & B12 especially)

B vitamins, specifically B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin), are essential for maintaining a healthy nervous system and supporting inner ear neurons. These neurotropic B vitamins act as coenzymes and protect nerves from damage, contributing to the transmission of auditory signals to the brain. Deficiencies in these vitamins can lead to neurological diseases or malfunctions, but even without a proven deficiency, they can improve certain neurological conditions. Therefore, B vitamins are crucial for providing neurological support and protecting the nerves, especially the spiral ganglion neurons (SGNs) responsible for transferring auditory signals to the brainstem.


The eriodictyol glycoside found in bioflavonoids can improve microcirculation and prevent fatty deposits in the inner ear, while also potentially blocking histamine production. These bioflavonoids have been clinically proven over 60 years to relieve vertigo and tinnitus symptoms. Additionally, hesperetin, a derivative of eriodictyol, can prevent neurodegenerative diseases by reversing the factors that cause them, such as oxidative stress and neuroinflammation. Its ability to inhibit apoptotic cell death makes hesperetin a promising ingredient to supplement your diet for preventing and treating neurodegenerative conditions.

Ginkgo Biloba

Ginkgo Biloba is the workhorse of this formula because it helps potentially inflamed areas of the head and ear improve blood flow, helping inner ear functionality and ensuring the other ingredients are able to reach the areas they need to be effective. It is believed to improve blood flow throughout the inner ear by dilating blood vessels and reducing blood viscosity, which can enhance circulation to the small capillaries and hair cells in the ear. It also has antioxidant properties that can protect against oxidative stress and reduce inflammation in the inner ear, which may contribute to hearing loss and other inner ear disorders. Additionally, Ginkgo Biloba may improve neurotransmitter function in the brain and enhance cognitive function, which can help with processing sound and improving overall hearing ability.

Explore our full family of ear health products

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

*Survey data on file


What is hearing loss and What are the causes of hearing loss

  1. “Slideshow: Top Causes of Hearing Loss.” WebMD, Accessed 1 June 2023.

Treatment Options for Hearing Loss

  1. “Hearing LossTreatment.” UCSFHealth.Org, Accessed 1 June 2023.

Hearing Support Ingredients and Mechanism of Action

  1. “Folic acid supplementation slowed the decline in hearing of the speech frequencies associated with aging in a population”
    Durga J, et al: Effects of folic acid supplementation on hearing in older adults: a randomized, placebo-controlled trial. Ann Intern Med. 2007 Jan 2;146(1):1-9
  2. “Our findings demonstrate, for the first time, the relationship between hyperhomocysteinemia induced by folate deficiency and premature hearing loss involves impairment of cochlear Hcy metabolism and associated oxidative stress”
    Martinez-Vega R, et al: Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism. FASEB J 2015 Feb;29(2):418-32
  3. “Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) contribute essentially to the maintenance of a healthy nervous system. Their importance is highlighted by many neurological diseases related to deficiencies in one or more of these vitamins, but they can improve certain neurological conditions even without a (proven) deficiency”.
    Calderón-Ospina, C: B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin, CNS Neurosci Ther 2020 Jan;26(1):5-13
  4. “The ability of hesperetin to reverse the different inducers of neurodegenerative diseases, including elevated oxidative stress, neuroinflammation, and apoptotic cell death, making hesperetin a candidate drug for the prevention of neurodegenerative conditions”.
    Khan, A: Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders, Antioxidants (Basel). 2020 Jul; 9(7): 609

Folate, B vitamins, antioxidants/vitamin C

  1. Houston DK, Johnson MA, Nozza RJ, Gunter EW, Shea KJ, Cutler GM, Edmonds JT. Age-related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin Nutr. 1999 Mar;69(3):564-71. doi: 10.1093/ajcn/69.3.564. PMID: 10075346.
  2. Curhan SG, Stankovic KM, Eavey RD, Wang M, Stampfer MJ, Curhan GC. Carotenoids, vitamin A, vitamin C, vitamin E, and folate and risk of self-reported hearing loss in women. Am J Clin Nutr. 2015 Nov;102(5):1167-75. doi: 10.3945/ajcn.115.109314. Epub 2015 Sep 9. PMID: 26354537; PMCID: PMC4625586.
  3. Collaboration HLT. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ. 1998 Mar 21;316(7135):894-8. PMID: 9569395; PMCID: PMC28491.
  4. Lasisi AO, Fehintola FA, Yusuf OB. Age-related hearing loss, vitamin B12, and folate in the elderly. Otolaryngol Head Neck Surg. 2010 Dec;143(6):826-30. doi: 10.1016/j.otohns.2010.08.031. Epub 2010 Oct 25. PMID: 21109085.
  5. Gocer C, et al (2009) Homocysteine, Folate and Vitamin B12 Concentrations in Middle Aged Adults Presenting with Sensorineural Hearing Impairment Int. Adv. Otol. 2009; 5:(3) 340-344
  6. Karli R, Gül A, Uğur B. Effect of vitamin B12 deficiency on otoacoustic emissions. Acta Otorhinolaryngol Ital. 2013 Aug;33(4):243-7. PMID: 24043911; PMCID: PMC3773962
  7. Petridou AI, Zagora ET, Petridis P, Korres GS, Gazouli M, Xenelis I, Kyrodimos E, Kontothanasi G, Kaliora AC. The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial. Nutrients. 2019 Dec 12;11(12):3037. doi: 10.3390/nu11123037. PMID: 31842394; PMCID: PMC6950042.


  1. Nguyen T, Alzahrani T. Ginkgo Biloba. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan-. Available from:


  1. Creston JE, Gillespie MR, Larson AL. Bioflavonoid Therapy in Sensorineural Hearing Loss: A Double-Blind Study. Arch Otolaryngol. 1965;82(2):159–165. doi:10.1001/archotol.1965.00760010161015